In Reply We appreciate the thoughtful critique by Tang and Zhou regarding the Delayed Cord Clamping With Oxygen in Extremely Preterm Infants (DOXIE) trial. They highlight that the baseline differences in our maternal outcomes (chorioamnionitis, duration of rupture of membranes, and cesarean delivery rates) may have contributed to the differences in our primary outcome. While these outcomes have been shown to have impacts on clinical outcomes in premature infants, we respectfully disagree with the assertion that adjustment for baseline covariates is necessary to ensure valid inference in a randomized clinical trial (RCT).
Clinical Practice Guidelines