For the last 3 years, I have begun this review by stating it has been an extraordinary year for JAMA Pediatrics. I mean it this time! The calendar year coincides almost perfectly with the start of the coronavirus disease 2019 (COVID-19) pandemic, and for all of the misery it brought, it also generated an enormous amount of research. We received more than 1000 COVID-19–related manuscripts from all over the world. In part because of these, our overall submissions were up 53%, and our acceptance rate for the year was 5% (down from 8% last year). In 2020, the top-viewed articles were all related to COVID-19, as were 2 of the top 3 articles by Altmetric score (a measure of news and social media attention) and the top 3 most cited articles. There remain unanswered questions related to COVID-19, and we are seeking manuscripts that address those. And in the pandemic’s anticipated wake, we expect many articles that continue to demonstrate what the long-term effects will be on children as they slowly return to some sense of normalcy.