The Original Investigation titled “Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial” was corrected to fix the first paragraph of the Introduction, which had incorrectly indicated that NICU costs were approximately $26 billion annually; the correct value is $17 billion, which reflects the cost of neonatal hospitalizations inclusive of those in the NICU. An irrelevant reference associated with the erroneous text was also removed.