Clinical Practice Guidelines

Errors in Abstract and Author Name

The Original Investigation titled “Changes Induced by Early Hand-Arm Bimanual Intensive Therapy Including Lower Extremities in Young Children With Unilateral Cerebral Palsy: A Randomized Clinical Trial,” published on November 6, 2023, was corrected to fix an error in the Abstract; “This prospective randomized clinical trial (November 2018 to December 2021), including 2 parallel groups and a 1:1 allocation, took place at European university hospitals…” was updated to “This prospective randomized clinical trial (November 2018 to December 2021), including 2 parallel groups and a 1:1 allocation, recruitment took place at European university hospitals…”; in the Key Points, “What is the effect of early Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) intervention on bi...

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Clinical Practice Guidelines

Influenza Vaccination in Pregnancy—Rolling Up Sleeves for Pregnant Persons and Infants

As the world transitions from COVID-19 pandemic to endemic, influenza continues to adapt and challenge our immune systems and our public health initiatives. Influenza remains an important respiratory illness among all populations, including pregnant persons and infants, who both have increased susceptibility to severe disease. Notably, infants younger than 6 months have the highest hospitalization rate of all children. Maternal influenza vaccination protects expectant persons from illness and its complications as well as infants in the first 6 months of life through transplacental transfer of antibodies. The US Centers for Disease Control and Prevention and American College of Obstetricians and Gynecologists recommend inactivated influenza vaccination be administered during the influenza s...

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Clinical Practice Guidelines

Error in Figure

The Original Investigation titled “Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants: A Systematic Review and Network Meta-Analysis,” published on November 6, 2023, was corrected to fix 2 errors in the row headings for Figure 3. This article was corrected online.

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Clinical Practice Guidelines

Child Welfare Youth—Psychotropic Use and Implications

To the Editor The study by Radel et al on psychotropic medications and polypharmacy among children and adolescents in the US child welfare system warrants discussion. The results reiterate prevailing concerns regarding high prescription rates in this vulnerable population. The notable discrepancy, with 26.25% of youths in the child welfare system prescribed psychotropic medication compared to 9.06% of Medicaid-enrolled youths, underscores a concern in prescription practices. The 13.27% experiencing psychotropic polypharmacy emphasizes a potential overreliance on pharmacologic interventions.

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Clinical Practice Guidelines

What Health Systems Can Do Now to Improve HPV Vaccination

The human papillomavirus (HPV) vaccine could prevent an estimated 94% of HPV-attributable or 36 500 total cancers in the United States each year. Despite this effectiveness, vaccine coverage is lower than other routine adolescent immunizations. In 2022, for the first time since 2013, HPV vaccine series initiation did not increase among adolescents. This concerning finding highlights the need for large-scale measures to support HPV vaccination. Because a majority of vaccination occurs in primary care settings, it makes sense to focus on improving the effectiveness of primary care vaccination efforts. Furthermore, an increasing number of primary care practices are part of health systems. Immunization efforts coordinated at the health system level have the potential to increase HPV vaccine co...

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Clinical Practice Guidelines

Contextualizing Depression in Pacific Islander Sexual and Gender Minority Youth—Location, History, and Culture

To the Editor The study by Rider et al identified high rates of depressive symptoms among groups of Asian American and Native Hawaiian and Other Pacific Islander youth of sexual and gender minority identities who experienced bias-based bullying. We applaud the authors for investigating a vital intersection of pediatric, sexual and gender minority, and mental health. They implemented the χ2 automatic interaction detection technique—a decisional tree approach developed in the 1980s that was foundational to modern-day gradient boosting machine learning techniques used in health care research. Using surveys from California and Minnesota, they found depressive symptoms among the aggregate grouping of Filipinx, Korean, and Japanese youth. As Indigenous Native Hawaiian and Other Pacific Islander ...

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Clinical Practice Guidelines

Error in Affiliations

The Original Investigation titled, “Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight: A Systematic Review and Network Meta-Analysis,” published October 9, 2023, incorrectly listed the Department of Environmental Health, T. H. Chan School of Public Health, Boston, Massachusetts, as an affiliation for Dr López-Gil. The article has been corrected to remove this affiliation.

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Clinical Practice Guidelines

Safety and Benefits of COVID-19 Vaccination in Pregnancy—Implications for the Maternal Vaccination Platform

The development of safe and effective vaccines against the novel SARS-CoV-2 virus, the cause of COVID-19 pandemic, was justifiably hailed as a major advance in protecting the population against severe and fatal infection. The vaccine rollout was targeted toward recognized communities at risk, including older adults, those with comorbidities, and those who were immunosuppressed. Pregnant women, and by extension, their infants, were included in these high-risk groups for vaccination. The prioritization of pregnant women was justified from historical observations of disproportionate mortality and morbidity during previous influenza pandemics. For example, during the 1918 Spanish influenza pandemic, 50% of infected pregnant women died. Despite advances in public health, intensive care, and the...

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Clinical Practice Guidelines

Errors in Text, Table, and Figure

In the Research Letter titled “Trends in Obesity Prevalence Among Children and Adolescents Aged 2 to 19 Years in the US From 2011 to 2020,” published online first on July 25, 2022, and in the October 2022 issue of JAMA Pediatrics, there was an error in the analyses of the mobile examination clinic (MEC) weights. During the final analysis, the weights were removed so as to include race and ethnicity as a covariate. Per the National Health and Nutrition Examination Survey, inclusion of the MEC weights is necessary to make the prevalence data nationally representative. To address this error, calculations were performed again to include MEC weights through all stages of the analyses. As a result, the updated analyses resulted in corrections to many of the prevalence rates reported in the text,...

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Clinical Practice Guidelines

Reevaluating the Association Between Autism and Lithium Exposure During Pregnancy—Reply

In Reply In response to our article, Barbanti Zancheta et al asked why we did not include some known risk factors for autism as confounders in our models. We left out gestational age as it is likely a mediator in the causal pathway that would induce bias if included, while there is no apparent reason to think that paternal age or child age at diagnosis affects maternal residential lithium exposure levels. In terms of the study design and effect estimates we chose, we would like to point out that a nested case-control design is a well established and cost-efficient epidemiologic approach to estimate exposure effects (odds ratios) for rare outcomes. We extracted autism spectrum disorder (ASD) diagnoses—primarily made by child psychiatrists following International Statistical Classification o...

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Clinical Practice Guidelines

Probiotics, Prebiotics, and Lactoferrin in Preterm Infants

Prematurity is a major problem in the United States and globally. Preterm infants born at very low birth weight (<1500 g) experience increased mortality (7%-22%), and only 58% to 74% of these infants survive without the major morbidities of bronchopulmonary dysplasia, severe intraventricular hemorrhage, cystic periventricular leukomalacia, or retinopathy of prematurity requiring treatment. Preterm survivors are at risk of having long-term morbidity, including cerebral palsy, intellectual disabilities, blindness, and hearing loss. During 2008 to 2016, the annual societal economic cost associated with preterm birth in the United States was at least $26.2 billion. During the first 6 months of life, mean first-year medical costs were about 10 times greater for preterm infants ($76 153) than...

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Clinical Practice Guidelines

Reconsidering the Diagnostic Construct Validity of Depressive Disorders for Young Children

Depression is a leading cause of global disease burden and premature death, with early age at depression onset portending poorly for a host of negative outcomes. Children who experience depression are at risk of having a more severe course of illness, including a greater number of and more severe episodes, increased risk of suicide attempts, greater number of hospitalizations, more medical and psychiatric comorbidity, and greater impairment in social, cognitive, and occupational functioning, compared with onset in adolescence or adulthood. The treatment costs for childhood mental disorders in the US are estimated to be $10.9 billion annually. Thus, from a public health standpoint, it is critical to ascertain a clear understanding of the earliest emergence of depressive disorders and their ...

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Clinical Practice Guidelines

Epigenetics of Early-Life Socioeconomic Stressors and the Impact on Childhood Body Mass Index—Potential Mechanism and Biomarker?

Overweight and obesity are growing epidemics worldwide. Recent estimates from the World Health Organization indicate that 39% of adults had overweight, and 13% had obesity. In addition, an estimated 340 million children and adolescents aged 5 to 19 years had overweight or obesity in 2016 whereas 39 million children younger than 5 years had overweight or obesity in 2020. Understanding the biological mechanisms behind the development of overweight and obesity is critical as overweight and obesity are risk factors for a host of cardiometabolic outcomes including heart disease, stroke, diabetes, and chronic kidney disease. The developmental origins of health and disease hypothesis points to the importance of long-term epigenetic programming for cardiometabolic risk factors such as high body ma...

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Clinical Practice Guidelines

Epidemiologic, Public Health, and Clinical Implications of Death Among Preterm Infants in the US

In JAMA Pediatrics, Venkatesan et al share a rigorous, descriptive, epidemiologic analysis of more than 100 million US births from 1995 to 2020. The authors focus on mortality rates specifically among the more than 12 million preterm infants and highlight a few key findings. Mortality rates among preterm infants have declined substantially over the last 25 years from 33.7 to 23.3 per 1000 live births. However, inequities in preterm infant mortality persist; Black preterm infants remain 43% more likely to die than their White counterparts. Black extremely preterm infants (22-27 weeks gestation) have a small (13%) subtle survival advantage over White extremely preterm infants, which was stable throughout the study period. With respect to socioeconomic and demographic variables, infants born ...

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Clinical Practice Guidelines

Preterm Prenatal Education—A Novel Approach

Preterm birth (ie, birth before 37 weeks’ gestational age) is the leading cause of mortality in children younger than 5 years worldwide and accounts for 18% of the deaths. Furthermore, preterm birth is a common cause of morbidity and further mortality during childhood. The most common complications of prematurity include respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, feeding difficulties, interventricular hemorrhages, periventricular leukomalacia, seizures, sepsis, and retinopathy of prematurity. While there is higher morbidity and mortality associated in infants born before 34 weeks’ gestation, those born between 34 and 37 weeks’ gestation (defined as late preterm) are at risk for greater adverse outcomes than term infants. Mothers of preterm infants...

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Clinical Practice Guidelines

Disaggregating Racial and Ethnic Data to Examine Intersectional Identities, Bias-Based Bullying, and Mental Health

Intersectional theory underscores the ways in which an individual’s diverse social identities may interact with one another to shape a person’s lived experiences. This perspective emerged, in part, as a response to concerns that focusing on a single axis of oppression, such as racism or sexism, may ignore the unique experiences of individuals who experience marginalization along multiple dimensions (eg, both racism and heterosexism). Research grounded in intersectionality that examines how social identities uniquely contribute to experiences of discrimination and associated health outcomes is imperative for guiding prevention and intervention approaches tailored to the lived experiences of diverse youth.

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Clinical Practice Guidelines

Plain Language Formatting of Health Advice Messages and Accessibility and Understanding

Research on persuasion and advice utilization has several implications and best practices for constructing health advice messages. In the randomized clinical trial by Stallwood et al, youth participants were given either plain language COVID-19 health recommendations (PLR) or standard language version recommendations (SLV). The primary result of the study showed there were no significant differences in scores on questions testing understanding between the 2 formats, but participants exposed to the PLR format demonstrated slightly higher scores. Results of the study confirm previous research and recommendations for the effective construction of advice messages. Specifically, participants perceived PLR-formatted messages as more accessible, more satisfying, and having higher usability than t...

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Clinical Practice Guidelines

COVID-19 in Children—Learning From the Past, Planning for the Future

As of April 2023, over 39 million children worldwide have been infected with SARS-CoV-2. Now entering the fourth year after COVID-19 was declared a pandemic in March 2020, children have been at the forefront of dialogues around school closures, mask mandates, and vaccination campaigns. Fundamental to these discussions lies a need to quantify the impact of COVID-19 on children—and in order to optimize child health now and in the future, we must learn from our past.

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Clinical Practice Guidelines

Promoting the Use of Modern Communication Tools to Increase Vaccine Uptake in Pregnancy

To the Editor The research article published by Skoff et al reported that, following maternal diphtheria toxoid and acellular pertussis vaccine introduction, a sustained decrease in pertussis incidence was observed in infants younger than 2 months. A slope of −14.53 per 100 000 infants per year from before to after implementation during pregnancy has been calculated. Modern approaches in prenatal communication may be relevant to this study.

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Clinical Practice Guidelines

Poor Mental Health Among Survivors of Childhood Cancer—Risk Factors and a Call for Intervention

Despite consistent evidence suggesting high rates of physical and psychosocial morbidity among survivors of childhood cancer, debate has persisted: are those who are diagnosed with cancer as children, adolescents, or young adults ([CAYAs] 0 to 25 years old) at higher risk than their siblings or peers for depression, anxiety, suicide, or other mental health disorders? The article by Lee et al in this issue of JAMA Pediatrics provides the most definitive answer to date: yes. In their systematic review and meta-analysis of data from 52 studies and over 20 000 CAYA cancer survivors, they confirmed lifetime elevated risks of depression (relative risk [RR], 1.57; 95% CI, 1.29-1.92), anxiety (RR, 1.29; 95% CI, 1.14-1.47), and other psychiatric illnesses (ie, schizophrenia, RR, 1.56; 95% CI, 1.36...

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Clinical Practice Guidelines

Current and Future Challenges Regarding Estimating Costs to Determine the Value of Interventions to Manage Unhealthy Weight

Large systems-level changes are needed to address the high prevalence of childhood obesity in the US. In a world with many competing priorities, stakeholders need to understand the value of investing in childhood obesity policy changes to prioritize funding clinical and policy interventions. The study by Kumar et al in this issue of JAMA Pediatrics aims to estimate the association between children’s body mass index (BMI) class and medical expenditures in the US. Using electronic medical record (EMR) and claims data for privately insured youth, this cross-sectional study found that, relative to healthy weight, having underweight, overweight, and moderate and severe obesity were associated with higher total health care expenditures among those aged 2 to 19 years in 2018.

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Clinical Practice Guidelines

Using Modern Modalities to Improve Population Health and Advance Food and Health Equity—Reply

In Reply We appreciate the commentary from Kalyanaraman Marcello highlighting produce delivery as a modality for improving food access. We agree that produce delivery models reduce barriers for households that cannot easily access vegetables and fruits from local purveyors, such as grocery stores or farmers markets, and thus may be an important component of an equitable system.

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Clinical Practice Guidelines

Using Modern Modalities to Improve Population Health and Advance Food and Health Equity

To the Editor I appreciated the recent Viewpoint by Virudachalam et al highlighting the critical need to expand produce prescription programs to children as a means to advance food equity. As the principal investigator of Food for Health, a randomized clinical trial of a produce prescription program for children at New York City Health + Hospitals, the nation’s largest public health care system, I wholeheartedly agree with the authors’ sentiments. However, I regret that they overlooked the rapidly growing modality of home delivery of fruits and vegetables, which eliminates multiple barriers to inequitable fruit and vegetable access and stands to play an important role in advancing food and health equity.

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Clinical Practice Guidelines

Prehospital Transfusion in Pediatric Trauma—The Clock Is Ticking

Trauma is the leading cause of mortality and hemorrhagic shock in pediatric patients, and sustained injuries are one of the most common causes of preventable mortality in these patients. An estimated 1000 to 2000 preventable traumatic deaths in children per year occur after injury in the US because of inadequate or delayed care. Some of these deaths may represent pediatric patients with unrecognized hemorrhagic shock who are not promptly treated with hemorrhage control and appropriate hemostatic resuscitation. The 30-day mortality in children with traumatic hemorrhagic shock is estimated to be 36% to 50% compared with the 25% reported mortality in similar adults. A retrospective review of the Pennsylvania statewide trauma database by Morgan et al aimed to determine if the utilization of pr...

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Clinical Practice Guidelines

Error in Author’s Name

In the Original Investigation titled “Psychometric Properties of Screening Instruments for Social Network Use Disorder in Children and Adolescents: A Systematic Review,” published online February 20, 2023, the 10th author’s surname was misspelled in the byline. The author’s name has been corrected to Zsolt Demetrovics, PhD. This article was corrected online.

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Clinical Practice Guidelines

What Is the Optimum Approach to Screening for Familial Hypercholesterolemia in Children?

The area of screening and treatment for dyslipidemia in children and adolescents has been controversial. One reason for this is that dyslipidemia is heterogeneous with multiple underlying causes, including genetic and lifestyle causes. One area that is less controversial is that of familial hypercholesterolemia (FH). Familial hypercholesterolemia is due to a genetic abnormality impacting the structure, function, or metabolism of the low-density lipoprotein (LDL) receptor, resulting in elevated plasma LDL cholesterol (LDL-C). There is a variety of gene variants that can underlie FH, including those involving the LDL receptor, apolipoprotein B, or proprotein subtilisin/kexin type 9 (PLSK9), which result in marked elevation of plasma LDL-C from birth and, without intervention, throughout life...

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Clinical Practice Guidelines

The Price of Admission—the Financial Burden of Out-of-Pocket Hospital Costs for Children

Requiring hospital care can be stressful for children and their families, and this stress can continue after discharge when the hospital bill arrives. As documented by Carlton et al, out-of-pocket costs for children’s hospitalizations can be substantial. In their study of commercial claims for 183 780 non–birth-related hospitalizations from 2017 to 2019 for children aged 0 to 18 years measured in national MarketScan claims data, they found that the mean out-of-pocket cost per hospitalization was $1313 and exceeded $3000 for 14% of hospitalizations. Not surprisingly, children in high-deductible health plans had higher out-of-pocket costs per hospitalization. Relatedly, hospitalizations in the first part of the calendar year incurred higher out-of-pocket costs, presumably because annual dedu...

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Clinical Practice Guidelines

Screening Success in the Age of Autism

Efforts directed at the early identification of autism spectrum disorder (ASD) in children began more than 2 decades ago. Movement toward universal screening in pediatric practices began with publication of the Modified Checklist for Autism in Toddlers (M-CHAT) in 2001, followed by American Academy of Pediatrics (AAP) guidance in use of this and similar tools in 2006.

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Clinical Practice Guidelines

Time to End Community Acquired as an Adjectival Diagnosis for Pneumonia

To the Editor The review of antibiotic therapy for children with nonsevere community-acquired pneumonia by Li et al found that shorter courses of antibiotics were not inferior to longer courses of antibiotics. But are even low doses of antibiotics routinely indicated for so-called community-acquired pneumonia? In fact, a study of children who met the World Health Organization’s criteria for community-acquired pneumonia demonstrated that the outcome of children receiving no antibiotics was not inferior to the outcome in children who received antibiotics. That result is consistent with the viral etiology of most children hospitalized for community-acquired pneumonia.

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Clinical Practice Guidelines

Time to End Community Acquired as an Adjectival Diagnosis for Pneumonia—Reply

In Reply We appreciate the interest in our article comparing a shorter and a longer course of antibiotic therapy for nonsevere community-acquired pneumonia (CAP) in children. First, Weinberger suggests replacing community acquired with viral or bacterial as the adjectival phrase for pediatric pneumonia. Our systematic review included children who met the diagnostic criteria for CAP. The included studies did not provide information on the etiologic pathogens of these patients, nor did they diagnose patients with bacterial or viral pneumonia. As a result, we can only define the study population as having CAP based on the available data. This issue was addressed in the article’s Discussion section.

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Clinical Practice Guidelines

Autism, Physical Health Conditions, and a Need for Reform

Currently, 1 in 44 children receive an autism diagnosis by the age of 8 years in the United States; despite improvements in recognition of autism, autistic people still have poor long-term outcomes regarding their health and health care. Overall, autistic people are dying much younger than expected, with several studies now suggesting that autistic people are, on average, dying 12 to 30 years younger than others. Unfortunately, risk of dying by suicide is also elevated among autistic people, with as many as 1 in 3 reporting a previous suicide attempt. However, the growing literature on premature mortality also points to physical health problems that are currently underresearched and underexplored. In particular, there is a paucity of research on the chronic physical health problems among a...

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Clinical Practice Guidelines

Error in Text

In the Original Investigation titled “Telehealth Treatment of Behavior Problems in Young Children With Developmental Delay: A Randomized Clinical Trial,” published online January 9, 2023, the Results section of the Abstract and article body incorrectly listed children’s age in years instead of months. This article has been corrected online.

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Clinical Practice Guidelines

Unlocking the Promise of Physical Activity for Mental Health Promotion

Physical activity is remarkable medicine. The 2018 Physical Activity Guidelines for Americans reported 27 major physical and mental health benefits with strong research support, all of which are compelling (eg, lower all-cause mortality). Among these benefits, 9 were denoted as new for 2018. These new benefits are, of course, not new in the sense that active people in the past did not receive them; rather, they are new in the sense that sufficient evidence arose in meta-analyses to affirm them. In their systematic review and meta-analysis published in this issue of JAMA Pediatrics, Recchia et al extend the evidence on health benefits of physical activity. Their meta-analysis includes data from more than 2400 youth who participated in more than 20 randomized clinical trial and quasi-experim...

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Clinical Practice Guidelines

New JAMA Policy for Public Access to Scientific Research Findings and Principles of Biomedical Research

Timely access to scientific research findings for the broadest possible audience is a principle on which sound science is based. Access to new findings helps other scientists adjust their hypotheses and open new lines of inquiry, thereby supporting and accelerating further discovery and innovation. For those who rely on newly generated evidence to develop policies and define practices that improve medicine and public health, rapid and equitable access is critical. The principle of broad access is a cornerstone of transparency, reinforces rigor and reproducibility, and ultimately, is critical to all stakeholders’ trust in science.

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Clinical Practice Guidelines

Labeling Errors in Flow Diagram

In the Original Investigation titled “Inhaled Corticosteroids Alone and in Combination With Long-Acting β2 Receptor Agonists to Treat Reduced Lung Function in Preterm-Born Children: A Randomized Clinical Trial,” published online December 13, 2021, and in the February 2022 issue, there were labeling errors in the flow diagram. In the rightmost rectangle below the “53 Randomized” oval, the label reading “14 ICS with LABA” should have been “14 Placebo.” In the leftmost rectangle, the label reading “20 ICS with LABA” should have read “20 ICS.” This article was corrected online.

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Clinical Practice Guidelines

Documenting Racial Disparities or Disrupting Racism?

As research in psychological and medical sciences attempts to acknowledge and address racist systems, we must keep a keen eye on justice and avoid the pitfalls of making systems of power and oppression invisible. Toward this effort, we contend that studies that highlight racial disparities should also name and define racism and identify systems of inequality within a sociohistorical context.

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Clinical Practice Guidelines

New Screening Tool for Term-Born Infants Enables Update to the Clinical Practice Guideline for Early Diagnosis of Cerebral Palsy

Rouabhi et al present a novel prognostic tool for identifying the risk of cerebral palsy (CP) in a “low-risk” term newborn, using a large sample of population register data from Canadian infants. Selected clinical variables based on published risk factors were used to build and test a model. Variables not contributing to the model were removed, enabling development of a streamlined prognostic tool. The authors identified 12 clinical variables for inclusion within the tool, all of which are routinely collected clinical information about pregnancy and maternal history (eg, preeclampsia, tobacco use), labor and delivery history (eg, prolonged rupture of membranes, Apgar scores), and infant characteristics (eg, sex, birth weight). The tool calculates a prediction value for risk of CP and gives...

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Clinical Practice Guidelines

Cerebral Palsy and Maternal Injury During Pregnancy

Cerebral palsy (CP) remains the most common lifelong physical disability condition in childhood, affecting about 2 to 4 children per 1000 live births each year in high-income countries. The etiological causes for most CP cases remain unknown, and only a few perinatal risk factors, such as birth asphyxia, preterm delivery, and infections, have been identified. Ahmed and colleagues conducted a large medical linkage cohort study of CP that included more than 2 million mothers and children living in Ontario, Canada, and reported that maternal unintentional injury during pregnancy was associated with a higher risk for CP in the offspring (hazard ratio, 1.33; 95% CI, 1.18-1.50). The study showed that maternal injuries that were severe, such as those resulting in hospitalization or having to deli...

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Clinical Practice Guidelines

Errors in Funding/Support

The Original Investigation titled “Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years: Follow-up of a Randomized Clinical Trial,” published online November 21, 2022, listed incomplete and inaccurate Funding/Support information regarding grants received from the National Institutes of Health. The Article Information section has been updated to include the correct Funding/Support information.

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Clinical Practice Guidelines

Error in the Text

In the Editorial titled “The US Mental Health System Is So Broken That Even Money Can’t Fix It,” which published online November 21, 2022, a name in the fourth paragraph of the text was misspelled. The correct spelling is Hoffmann. This article has been corrected online.

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Clinical Practice Guidelines

Contextual Considerations When Interpreting Well-Child Visit Adherence Results—Reply

In Reply Measuring well-child visit (WCV) adherence poses important measurement challenges, with no single method or data source best capturing all dimensions of this issue. We thank Goff for her interest in our research, and we agree our measure may have understated adherence. We nevertheless have concerns with the benchmarks she cites and alternative measures she suggests.

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Clinical Practice Guidelines

Error in Figure 1

In the Original Investigation titled “Incidence of Kawasaki Disease Before and After the COVID-19 Pandemic in Japan: Results of the 26th Nationwide Survey, 2019 to 2020” published online on October 17, 2022, there was a typographical error in Figure 1. The age range listed in the blue axis should be 0 to 59 months. This article was corrected online.

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Clinical Practice Guidelines

Migraine and Mental Health in Pediatrics

Migraine is one of the most common neurological conditions worldwide, affecting 5% to 10% of younger children and up to 25% of adolescent girls. Recurrent headaches can be extremely disabling and often prevent children from fully participating in school or extracurricular activities. Despite evidence that pediatric migraine is associated with poor quality of life and is causing a growing global economic burden, many basic questions about migraine management and factors that influence migraine remain unanswered. There is an ongoing need for rigorous studies in pediatric migraine, including an examination of comorbidities, migraine treatment options, and how management of comorbidities, like mood disorders, may affect migraine-related disability and outcomes.

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Clinical Practice Guidelines

Neurodiversity and Early Autism

To the Editor We appreciated the recent Viewpoint discussing neurodiversity and early intervention (EI) for autism. We share the authors’ concerns about systematic discrimination in the education and employment of individuals with diverse abilities and agree that society needs to accommodate both strengths and weaknesses. Having studied the loss of the autism spectrum disorder diagnosis, we agree that the loss of the diagnosis should not be a priority in EI for autistic children; rather, EI should focus on supporting them in language, social communication, adaptive behavior, and relationships. We endorse the long-term goals proposed by McCauley et al of autonomy, daily living skills, relationships, and employment or other activities outside the home in forms that are consistent with the in...

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Clinical Practice Guidelines

Neurodiversity and Early Autism

To the Editor As autistic physicians, we agree with the position of Dawson et al: the neurodiversity movement regards autistic individuals to be both neurodivergent (diverging from the neurotypical majority) and disabled by environments not designed for autistic flourishing. Neurodiversity-informed therapeutic interventions therefore emphasize modification of external factors to better fit the autistic person. Therapeutic attempts to alter factors within the person must be done with utmost care to maintain the person’s autistic identity while helping support integration in the neurotypical world.

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Clinical Practice Guidelines

Error in Abstract

The Original Investigation titled “Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy: A Systematic Review and Meta-analysis,” published on October 3, 2022, was corrected to fix an error reported in the Abstract; “chorioamnionitis (OR, 1.06; 95% CI, 0.86-1.31)” was updated to “chorioamnionitis (OR, 0.95; 95% CI, 0.83-1.07).” This article was corrected online.

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Clinical Practice Guidelines

Errors in Supplement

In the Research Letter “Detection of Messenger RNA COVID-19 Vaccines in Human Breast Milk,” published online first on September 26, 2022, there was an error in the eMethods in the Supplement. The study period was in 2021, not 2020. In addition, corrections were made to typographical errors in the eMethods text to fix punctuation and repetition. This article was corrected online.

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Clinical Practice Guidelines

Error in Table

In the Research Letter titled “Orphanhood and Caregiver Loss Among Children Based on New Global Excess COVID-19 Death Estimates,” published September 6, 2022, there was an error in the Table. The second subheading in the first column should be May 1, 2022. This article was corrected online.

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Clinical Practice Guidelines

Clarifying the Association of Individual Factors With Medical School Attrition

To the Editor The Research Letter by Nguyen and colleagues addresses the association between medical school attrition and mistreatment and discrimination. The conclusions of this study not only confirm the associations but also highlight issues related to sociodemographic factors. Here, we suggest some analytic considerations that may help the authors clarify the key messages from the study.

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Clinical Practice Guidelines

Cash Transfers and Reducing Child Poverty in the US

In this issue of JAMA Pediatrics, Copeland et al report on a 20-year follow-up of children, now adults, who were part of a natural experiment of cash transfers to some families. Due to an opening of a casino on the tribal lands located in the southeastern US, which coincided with an ongoing longitudinal cohort study of families called the Great Smoky Mountains Study, a coincidence allowed the study of outcomes of children receiving an exogenous income supplement compared with those who did not. This ongoing study helped address a long-standing and important question: Can investments in families early in the life course lead to better outcomes, especially for children living in poverty?

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Clinical Practice Guidelines

Modeling Cost and Outcomes of SARS-CoV-2 School Testing Programs—Reply

In Reply We thank Schuster et al for providing important context about school testing programs in response to our article. We wholeheartedly agree that schools, particularly those with English-language-learning and low-income student populations, have faced logistical barriers in implementing testing programs and that these challenges need to be considered in schools’ decisions about the role of testing.

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Clinical Practice Guidelines

Misconceptions About Youth Weight Lifting—Reply

In Reply We appreciate the comments from Brooks et al, who offer perspectives on youth weight lifting in response to our article “Physical Activity in Children.” As our article noted, children should engage in many types of activities, which importantly includes weight-bearing exercise. We appreciate these authors’ insights on the specifics of weight lifting in children, where they note that “well-designed weight lifting programs have no apparent negative effect on linear growth,” and encourage consensus in this area. We could not agree more.

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Clinical Practice Guidelines

Misconceptions About Youth Weight Lifting

To the Editor We read the article entitled “Physical Activity in Children” by Michel et al with great interest. The authors described troubling trends in youth physical activity that have worsened with the recent COVID-19 pandemic. We concur with the authors that different types of physical activity, including aerobic exercise (eg, jumping rope), muscle strengthening exercise (eg, push-ups), and bone strengthening exercises (eg, playing hopscotch), offer unique health and fitness benefits to children. Among several recommendations, the authors rightly emphasize the need to include all 3 types of exercise in a child’s routine for at least 60 minutes per day. However, the authors state that weight lifting (eg, strength training with dumbbells and barbells) is “not appropriate for younger chi...

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Clinical Practice Guidelines

Errors in Text, Figure, and Supplement

In the Research Letter titled “A Difference-in-Differences Analysis of Youth Smoking and a Ban on Sales of Flavored Tobacco Products in San Francisco, California,” published online first on May 24, 2021, and in the August 2021 issue of JAMA Pediatrics, there was an error in the time frame for the 2019 wave of the San Francisco district Youth Risk Behavior Surveillance System survey. The data were collected between November 5, 2018, and December 14, 2018, and not during the spring semester, as originally reported. To address this error, clarifications and corrections to the text of the article, the eMethods in the Supplement, and the label on the x-axis of Figure 1 have been made. In addition, a correction to the Conflicts of Interest Disclosures has been made to include the author’s disclo...

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Clinical Practice Guidelines

Racial Disparities in Lung Disease of Prematurity

Racial disparities in neonatal health are well documented. In the United States in 2019, the Black infant death rate was 10.6 per 1000 live births—more than double the rate of 4.5 in White infants. Between 2017 and 2019, the leading cause of Black infant mortality, preterm birth, was 52% higher in Black than in White infants. Among those born preterm, Black infants have higher rates of common morbidities. Although the incompletely characterized determinants of these disparities are multifactorial and complex, interpersonal and structural racism are key drivers.

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Clinical Practice Guidelines

Pediatric Patient Safety—First Steps Forward

For more than 2 decades, since the release of the Institute of Medicine’s groundbreaking report To Err is Human: Building a Safer Health System¸ hospitals and health care systems have struggled to understand and improve patient safety. On the basis of 2 large epidemiologic studies, the Institute of Medicine estimated in 1999 that 44 000 to 98 000 patients were being killed each year in the US due to medical errors and called for this rate to be halved within 5 years. The federal government and health systems responded to this call with an increased investment of funding and personnel committed to getting the patient safety epidemic under control. While our collective understanding of the human and systemic drivers of medical errors grew, it became painfully clear that the ambitious goal of...

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Clinical Practice Guidelines

More Recent Literature Does Not Support Premise or Conclusions

To the Editor Frost and Hersh argue that nearly 75% of antibiotics used for the treatment of acute otitis media (AOM) may be unnecessary. Their position hinges on a review article that quotes a study conducted 50 years ago, which they claim shows that symptoms in children with AOM caused by Hemophilus influenzae or Moraxella catarrhalis are more likely to resolve spontaneously without treatment compared with symptoms in children with Streptococcus pneumoniae. However, as all children in the above study had tympanocentesis at entry, its data cannot be used to estimate spontaneous resolution rates. More recent data suggest that H influenzae, not S pneumoniae, is more likely to be recovered from middle ears of children experiencing treatment failure. In our recent placebo-controlled trial, fa...

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Clinical Practice Guidelines

Options for Detecting Risk of Aminoglycoside-Induced Ototoxicity in Neonates—Reply

In Reply We are grateful to Mahmood and Leung for their interest in our article. They argue that there are more efficient ways to test for the MT-RNR1 m.1555A>G variant than the rapid point-of-care test (POCT) used in our study. They correctly state that m.1555A>G is subject to mitochondrial inheritance, and therefore knowing whether the mother was a carrier prior to delivery would negate the need for a rapid POCT. This biological assessment is sound, and testing every expectant mother for the variant would theoretically remove the need for rapid testing. However, this is neither cost-effective nor practicable.

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Clinical Practice Guidelines

Error in the Byline

In the Original Investigation titled “Association Between Screen Time Trajectory and Early Childhood Development in Children in China,” which published online online June 6, 2022, the second author’s name was misspelled. The correct spelling is Zhangsheng Yu, PhD. This article has been corrected online.

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Clinical Practice Guidelines

Error in Table Footnote

In the Original Investigation titled “Risk and Phenotype of Multisystem Inflammatory Syndrome in Vaccinated and Unvaccinated Danish Children Before and During the Omicron Wave,” published June 8, 2022, there was an error in the Table 1 footnotes. In footnote a, reference citations were added, and a multiplier was corrected. This article was corrected online.

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Clinical Practice Guidelines

Errors in Byline and Figure 2

In the Original Investigation titled “Reassessment of the Role of Race in Calculating the Risk for Urinary Tract Infection: A Systematic Review and Meta-analysis,” published online April 18, 2022, the second author’s middle initial was missing and the reference citations in Figure 2 were incorrect. The second author’s name has been corrected to Matthew C. Lee, BA, and the reference citations in Figure 2 have been updated. This article was corrected online.

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Clinical Practice Guidelines

Error in Author’s Name

In the Original Investigation titled “Childhood Asthma Incidence, Early and Persistent Wheeze, and Neighborhood Socioeconomic Factors in the ECHO/CREW Consortium,” published online May 23, 2022, an author’s name contained errors in the byline and contributions section. The author’s name has been corrected to Eneida A. Mendonça, MD, PhD. This article was corrected online.

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Clinical Practice Guidelines

Race, Overdose Deaths, and Years of Lost Life—Reply

In Reply Harris’s observations extend our research letter and provide evidence that is concordant with prior findings from our group. Previously, we found rates of unintentional opioid overdose mortality increasing faster among Black residents of Ohio compared with their White counterparts. We also found that experiences of racist mistreatment by health care workers are common among Black patients seeking addiction treatment and that a history of such experiences is related to medical mistrust, delay in seeking treatment for addiction, anticipation of racial discrimination during addiction treatment, and fear of discrimination-precipitated relapse. Further, it has been observed that the US addiction treatment workforce is predominantly White, and an increase in addiction treatment professi...

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Clinical Practice Guidelines

Taking a Hard Look at Community-Based Interventions in Obesity

A policy to subsidize neighborhood supermarkets is the center of a report by Rummo et al about a New York City (NYC), New York, initiative titled Food Retail Expansion to Support Health (FRESH). Given tax and zoning incentives, FRESH supermarkets are required to have a greater proportion of their store dedicated to fresh produce and grocery products. The program aims to amplify consumers’ ability to buy affordable, healthy foods. While the FRESH program did not have any meaningful association with changes in the grocery habits of adults and children, among individuals who lived within 0.50 miles of a FRESH-subsidized supermarket, there was an increase in self-reported intake of healthy foods and decreased intake of “unhealthy foods.”

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Clinical Practice Guidelines

Pandemic’s Paradoxical Effect on Child Health and Well-being

Like most existential threats, pandemics generate not only hardships but also hard choices. Clearly, the COVID-19 pandemic has profoundly disrupted the fabric of family and community life. However, it has also triggered emergency policy responses that have cut through years of muddled inaction on issues critical to child health and well-being. Many people are surprised to learn that now, 2 years into the pandemic, child poverty has fallen to historic lows. This is not the result of some long-term secular trend. Rather, it is the result of new, aggressive policy initiatives, initiatives that without immediate action will be abandoned in the coming months.

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